Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines

Interleukin-1 receptor-associated kinase 3 (IRAK3) modulates the magnitude of cellular responses to ligands perceived by interleukin-1 receptors (IL-1Rs) and Toll-like receptors (TLRs), leading to decreases in pro-inflammatory cytokines and suppressed inflammation. The molecular mechanism of IRAK3’s...

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Detalles Bibliográficos
Autores principales: Turek, Ilona, Nguyen, Trang H., Galea, Charles, Abad, Isaiah, Freihat, Lubna, Manallack, David T., Velkov, Tony, Irving, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217915/
https://www.ncbi.nlm.nih.gov/pubmed/37239919
http://dx.doi.org/10.3390/ijms24108572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10217915/
https://www.ncbi.nlm.nih.gov/pubmed/37239919
http://dx.doi.org/10.3390/ijms24108572

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