Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease

The papain-like protease (PL(pro)) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a critical role in the proteolytic processing of viral polyproteins and the dysregulation of the host immune response, providing a promising therapeutic target. Here, we report the structure-guid...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Chen, Guofeng, He, Jian, Li, Jiameng, Xiong, Muya, Su, Haixia, Li, Minjun, Hu, Hangchen, Xu, Yechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218254/
https://www.ncbi.nlm.nih.gov/pubmed/37239980
http://dx.doi.org/10.3390/ijms24108633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218254/
https://www.ncbi.nlm.nih.gov/pubmed/37239980
http://dx.doi.org/10.3390/ijms24108633

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