Dipeptide Nitrile CD34 with Curcumin: A New Improved Combination Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense

Rhodesain is the main cysteine protease of Trypanosoma brucei rhodesiense, the parasite causing the acute lethal form of Human African Trypanosomiasis. Starting from the dipeptide nitrile CD24, the further introduction of a fluorine atom in the meta position of the phenyl ring spanning in the P3 sit...

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Detalles Bibliográficos
Autores principales: Di Chio, Carla, Previti, Santo, Totaro, Noemi, De Luca, Fabiola, Allegra, Alessandro, Schirmeister, Tanja, Zappalà, Maria, Ettari, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218348/
https://www.ncbi.nlm.nih.gov/pubmed/37239824
http://dx.doi.org/10.3390/ijms24108477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218348/
https://www.ncbi.nlm.nih.gov/pubmed/37239824
http://dx.doi.org/10.3390/ijms24108477

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