Xenon’s Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice

Previous studies have shown that xenon reduces hyperpolarization-activated cyclic nucleotide-gated channels type-2 (HCN2) channel-mediated current (I(h)) amplitude and shifts the half-maximal activation voltage ([Formula: see text]) in thalamocortical circuits of acute brain slices to more hyperpola...

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Detalles Bibliográficos
Autores principales: Kassab, Nour El Dine, Mehlfeld, Verena, Kass, Jennifer, Biel, Martin, Schneider, Gerhard, Rammes, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218445/
https://www.ncbi.nlm.nih.gov/pubmed/37239964
http://dx.doi.org/10.3390/ijms24108613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218445/
https://www.ncbi.nlm.nih.gov/pubmed/37239964
http://dx.doi.org/10.3390/ijms24108613

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