Evolution of Resistance to Irinotecan in Cancer Cells Involves Generation of Topoisomerase-Guided Mutations in Non-Coding Genome That Reduce the Chances of DNA Breaks

Resistance to chemotherapy is a leading cause of treatment failure. Drug resistance mechanisms involve mutations in specific proteins or changes in their expression levels. It is commonly understood that resistance mutations happen randomly prior to treatment and are selected during the treatment. H...

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Detalles Bibliográficos
Autores principales: Kumar, Santosh, Gahramanov, Valid, Patel, Shivani, Yaglom, Julia, Kaczmarczyk, Lukasz, Alexandrov, Ivan A., Gerlitz, Gabi, Salmon-Divon, Mali, Sherman, Michael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218574/
https://www.ncbi.nlm.nih.gov/pubmed/37240063
http://dx.doi.org/10.3390/ijms24108717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218574/
https://www.ncbi.nlm.nih.gov/pubmed/37240063
http://dx.doi.org/10.3390/ijms24108717

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