Molecular Determinants of Species Specificity of α-Conotoxin TxIB towards Rat and Human α6/α3β4 Nicotinic Acetylcholine Receptors

Conotoxins are widely distributed and important for studying ligand-gated ion channels. TxIB, a conotoxin consisting of 16 amino acids derived from Conus textile, is a unique selective ligand that blocks rat α6/α3β2β3 nAChR (IC(50) = 28 nM) without affecting other rat subtypes. However, when the act...

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Detalles Bibliográficos
Autores principales: Xie, Ting, Qin, Yuan, Zhao, Jinyuan, Dong, Jianying, Qi, Panpan, Zhang, Panpan, Zhangsun, Dongting, Zhu, Xiaopeng, Yu, Jinpeng, Luo, Sulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218596/
https://www.ncbi.nlm.nih.gov/pubmed/37239959
http://dx.doi.org/10.3390/ijms24108618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218596/
https://www.ncbi.nlm.nih.gov/pubmed/37239959
http://dx.doi.org/10.3390/ijms24108618

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