Potential Ototoxicity of Insulin-like Growth Factor 1 Receptor Signaling Inhibitors: An In Silico Drug Repurposing Study of the Regenerating Cochlear Neuron Transcriptome

Spiral ganglion neurons (SGNs) connect cochlear hair cells with higher auditory pathways and their degeneration due to drug toxicity (ototoxicity) contributes to hearing loss. This study aimed to identify drug classes that are negatively correlated with the transcriptome of regenerating SGNs. Human...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertagnoli, Lino E., Seist, Richard, Batts, Shelley, Stankovic, Konstantina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218904/
https://www.ncbi.nlm.nih.gov/pubmed/37240591
http://dx.doi.org/10.3390/jcm12103485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218904/
https://www.ncbi.nlm.nih.gov/pubmed/37240591
http://dx.doi.org/10.3390/jcm12103485

Ejemplares similares