Evaluation of a Novel FKS1 R1354H Mutation Associated with Caspofungin Resistance in Candida auris Using the CRISPR-Cas9 System

Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of these mutations to echinocandin resistance remains...

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Detalles Bibliográficos
Autores principales: Kiyohara, Maiko, Miyazaki, Taiga, Okamoto, Michiyo, Hirayama, Tatsuro, Makimura, Koichi, Chibana, Hiroji, Nakada, Nana, Ito, Yuya, Sumiyoshi, Makoto, Ashizawa, Nobuyuki, Takeda, Kazuaki, Iwanaga, Naoki, Takazono, Takahiro, Izumikawa, Koichi, Yanagihara, Katsunori, Kohno, Shigeru, Mukae, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219442/
https://www.ncbi.nlm.nih.gov/pubmed/37233240
http://dx.doi.org/10.3390/jof9050529

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