Cargando…

Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA(A) Receptors without Affecting Synaptic Plasticity

Neurosteroids and benzodiazepines are modulators of the GABA(A) receptors, thereby causing anxiolysis. Furthermore, benzodiazepines such as midazolam are known to cause adverse side-effects on cognition upon administration. We previously found that midazolam at nanomolar concentrations (10 nM) block...

Descripción completa

Detalles Bibliográficos
Autores principales:	Puig-Bosch, Xènia, Ballmann, Markus, Bieletzki, Stefan, Antkowiak, Bernd, Rudolph, Uwe, Zeilhofer, Hanns Ulrich, Rammes, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219454/ https://www.ncbi.nlm.nih.gov/pubmed/37240402 http://dx.doi.org/10.3390/ijms24109056

Ejemplares similares

Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABA(A) Receptor Inhibition Require the δ-Subunit
por: Littlejohn, Erica L., et al.
Publicado: (2021)

Neuroprotective Actions of Neurosteroids
por: Borowicz, Kinga K., et al.
Publicado: (2011)

Neurosteroids and GABA-A Receptor Function
por: Wang, Mingde
Publicado: (2011)

Probing GABA(A) receptors with inhibitory neurosteroids
por: Seljeset, Sandra, et al.
Publicado: (2018)

Progesterone in the Brain: Hormone, Neurosteroid and Neuroprotectant
por: Guennoun, Rachida
Publicado: (2020)

Lack of Neurosteroid Selectivity at δ vs. γ2-Containing GABA(A) Receptors in Dentate Granule Neurons
por: Lu, Xinguo, et al.
Publicado: (2020)

The Mechanism of Enantioselective Neurosteroid Actions on GABA(A) Receptors
por: Tateiwa, Hiroki, et al.
Publicado: (2023)

Modulation of neurosteroid potentiation by protein kinases at synaptic- and extrasynaptic-type GABA(A) receptors
por: Adams, Joanna M., et al.
Publicado: (2015)

Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress
por: Gunn, Benjamin G., et al.
Publicado: (2011)

Multiple functional neurosteroid binding sites on GABA(A) receptors
por: Chen, Zi-Wei, et al.
Publicado: (2019)

Structural basis of neurosteroid anesthetic action on GABA(A) receptors
por: Chen, Qiang, et al.
Publicado: (2018)

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond
por: Zorumski, Charles F., et al.
Publicado: (2019)

Structural insights into opposing actions of neurosteroids on GABA(A) receptors
por: Legesse, Dagimhiwat H., et al.
Publicado: (2023)

Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization
por: Sugasawa, Yusuke, et al.
Publicado: (2020)

Neuroprotection by MKK7 inhibition in excitotoxicity
por: Vercelli, Alessandro, et al.
Publicado: (2015)

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABA(A) receptor subtype
por: Ralvenius, William T., et al.
Publicado: (2015)

Reduced neurosteroid potentiation of GABA(A) receptors in epilepsy and depolarized hippocampal neurons
por: Joshi, Suchitra, et al.
Publicado: (2020)

Extra-Synaptic GABA(A) Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABA(A) Modulating Steroid Antagonist
por: Bengtsson, Sara K. S., et al.
Publicado: (2023)

Neuroprotective function for ramified microglia in hippocampal excitotoxicity
por: Vinet, Jonathan, et al.
Publicado: (2012)

Contribution of Resting Conductance, GABA(A)-Receptor Mediated Miniature Synaptic Currents and Neurosteroid to Chloride Homeostasis in Central Neurons
por: Yelhekar, Tushar D., et al.
Publicado: (2017)

GABA(A) receptor-acting neurosteroids: A role in the development and regulation of the stress response
por: Gunn, Benjamin G., et al.
Publicado: (2015)

The Neuroprotective Effects of SIRT1 on NMDA-Induced Excitotoxicity
por: Yang, Xiaorong, et al.
Publicado: (2017)

During postnatal development endogenous neurosteroids influence GABA-ergic neurotransmission of mouse cortical neurons
por: Brown, Adam R., et al.
Publicado: (2016)

Neurosteroid Modulation of GABA(A) Receptor Function by Independent Action at Multiple Specific Binding Sites
por: Wang, Lei, et al.
Publicado: (2022)

New Hypoglycaemic Therapies
por: Gale, Edwin A M
Publicado: (2000)

The α2/α3GABA(A) receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice
por: Neumann, Elena, et al.
Publicado: (2021)

Neurosteroid Metabolites of Gonadal Steroid Hormones in Neuroprotection: Implications for Sex Differences in Neurodegenerative Disease
por: Mendell, Ari Loren, et al.
Publicado: (2018)

Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?
por: Wetten, Aaron, et al.
Publicado: (2022)

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
por: Yang, Le, et al.
Publicado: (2014)

Excitotoxicity-induced endocytosis as a potential target for stroke neuroprotection
por: Díaz-Guerra, Margarita
Publicado: (2020)

Neurosteroid effects in the central nervous system : the role of the GABA-A receptor
Publicado: (2004)

GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes
por: Bayón-Cordero, Laura, et al.
Publicado: (2022)

Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
por: Hulin, Mary W., et al.
Publicado: (2011)

Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience
por: Lüscher, Bernhard, et al.
Publicado: (2019)

Neurosteroids and brain function /
Publicado: (2001)

Research topic: neurosteroids
por: Vaudry, Hubert, et al.
Publicado: (2012)

Of cilia, titin, and neurosteroids
por: Adler, Elizabeth M.
Publicado: (2014)

Neurosteroids and Seizure Activity
por: Miziak, Barbara, et al.
Publicado: (2020)

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity
por: Lopes, João P, et al.
Publicado: (2013)

Xenon-mediated neuroprotection in response to sustained, low-level excitotoxic stress
por: Lavaur, J, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_eon81aiiffg25lg9rcrbioc7tf