Nitric oxide synthase and reduced arterial tone contribute to arteriovenous malformation

Mechanisms underlying arteriovenous malformations (AVMs) are poorly understood. Using mice with endothelial cell (EC) expression of constitutively active Notch4 (Notch4*(EC)), we show decreased arteriolar tone in vivo during brain AVM initiation. Reduced vascular tone is a primary effect of Notch4*(...

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Detalles Bibliográficos
Autores principales: Huang, Lawrence, Cheng, Feng, Zhang, Xuetao, Zielonka, Jacek, Nystoriak, Matthew A., Xiang, Weiwei, Raygor, Kunal, Wang, Shaoxun, Lakshmanan, Aditya, Jiang, Weiya, Yuan, Sai, Hou, Kevin S., Zhang, Jiayi, Wang, Xitao, Syed, Arsalan U., Juric, Matea, Takahashi, Takamune, Navedo, Manuel F., Wang, Rong A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219588/
https://www.ncbi.nlm.nih.gov/pubmed/37235659
http://dx.doi.org/10.1126/sciadv.ade7280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219588/
https://www.ncbi.nlm.nih.gov/pubmed/37235659
http://dx.doi.org/10.1126/sciadv.ade7280

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