Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere

Rad51 maintains genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs). Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres. Genetic and physical analyses show that srr1 and skb1 mutations redu...

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Detalles Bibliográficos
Autores principales: Mongia, Piyusha, Toyofuku, Naoko, Pan, Ziyi, Xu, Ran, Kinoshita, Yakumo, Oki, Keitaro, Takahashi, Hiroki, Ogura, Yoshitoshi, Hayashi, Tetsuya, Nakagawa, Takuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219947/
https://www.ncbi.nlm.nih.gov/pubmed/37237082
http://dx.doi.org/10.1038/s42003-023-04925-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219947/
https://www.ncbi.nlm.nih.gov/pubmed/37237082
http://dx.doi.org/10.1038/s42003-023-04925-9

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