Phosphorylation of IWS1 by AKT maintains liposarcoma tumor heterogeneity through preservation of cancer stem cell phenotypes and mesenchymal-epithelial plasticity

Chemotherapy remains the mainstay of treatment for patients with advanced liposarcoma (LPS), but response rates are only 25% and the overall survival at 5 years is dismal at 20–34%. Translation of other therapies have not been successful and there has been no significant improvement in prognosis for...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Zhang, Hongji, La Ferlita, Alessandro, Sp, Nipin, Goryunova, Marina, Sarchet, Patricia, Hu, Zhiwei, Sorkin, Michael, Kim, Alex, Huang, Hai, Zhu, Hua, Tsung, Allan, Pollock, Raphael E., Beane, Joal D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219984/
https://www.ncbi.nlm.nih.gov/pubmed/37237004
http://dx.doi.org/10.1038/s41389-023-00469-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219984/
https://www.ncbi.nlm.nih.gov/pubmed/37237004
http://dx.doi.org/10.1038/s41389-023-00469-z

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