Replacement of the Mouse LD(50) Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations

Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD(50)) assay has been commonly used to measure the potency of BoNT commercial preparations. As an alternative, we developed cell-based assays for abobotulinumtoxinA in both powder (Dysport(®), Azzalure(®...

Descripción completa

Detalles Bibliográficos
Autores principales: Fonfria, Elena, Marks, Elizabeth, Foulkes, Lisa-Marie, Schofield, Rebecca, Higazi, Daniel, Coward, Sam, Kippen, Alistair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220824/
https://www.ncbi.nlm.nih.gov/pubmed/37235349
http://dx.doi.org/10.3390/toxins15050314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220824/
https://www.ncbi.nlm.nih.gov/pubmed/37235349
http://dx.doi.org/10.3390/toxins15050314

Ejemplares similares