Cargando…
Replacement of the Mouse LD(50) Assay for Determination of the Potency of AbobotulinumtoxinA with a Cell-Based Method in Both Powder and Liquid Formulations
Botulinum neurotoxins (BoNTs) are important therapeutic agents. The in vivo median lethal dose (LD(50)) assay has been commonly used to measure the potency of BoNT commercial preparations. As an alternative, we developed cell-based assays for abobotulinumtoxinA in both powder (Dysport(®), Azzalure(®...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220824/ https://www.ncbi.nlm.nih.gov/pubmed/37235349 http://dx.doi.org/10.3390/toxins15050314 |