Targeting the PAI-1 Mechanism with a Small Peptide Increases the Efficacy of Alteplase in a Rabbit Model of Chronic Empyema

The incidence of empyema is increasing and associated with a mortality rate of 20% in patients older than 65 years. Since 30% of patients with advanced empyema have contraindications to surgical treatment, novel, low-dose, pharmacological treatments are needed. A Streptococcus pneumoniae-induced rab...

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Detalles Bibliográficos
Autores principales: Florova, Galina, De Vera, Christian J., Emerine, Rebekah L., Girard, René A., Azghani, Ali O., Sarva, Krishna, Jacob, Jincy, Morris, Danna E., Chamiso, Mignote, Idell, Steven, Komissarov, Andrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220965/
https://www.ncbi.nlm.nih.gov/pubmed/37242740
http://dx.doi.org/10.3390/pharmaceutics15051498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220965/
https://www.ncbi.nlm.nih.gov/pubmed/37242740
http://dx.doi.org/10.3390/pharmaceutics15051498

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