Chemical Analysis and Molecular Modelling of Cyclodextrin-Formulated Propofol and Its Sodium Salt to Improve Drug Solubility, Stability and Pharmacokinetics (Cytogenotoxicity)

Propofol is a widely used general anesthetic in clinical practice, but its use is limited by its water-insoluble nature and associated pharmacokinetic and pharmacodynamic limitations. Therefore, researchers have been searching for alternative formulations to lipid emulsion to address the remaining s...

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Detalles Bibliográficos
Autores principales: Wilhelms, Benedikt, Broscheit, Jens, Shityakov, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221165/
https://www.ncbi.nlm.nih.gov/pubmed/37242449
http://dx.doi.org/10.3390/ph16050667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221165/
https://www.ncbi.nlm.nih.gov/pubmed/37242449
http://dx.doi.org/10.3390/ph16050667

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