Structure Optimization of 12β-O-γ-Glutamyl Oleanolic Acid Derivatives Resulting in Potent FXR Antagonist/Modulator for NASH Therapy

The farnesoid X receptor (FXR) plays a crucial role in regulating the metabolism of bile acids, lipids, and sugars. Consequently, it is implicated in the treatment of various diseases, including cholestasis, diabetes, hyperlipidemia, and cancer. The advancement of novel FXR modulators holds immense...

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Detalles Bibliográficos
Autores principales: Ma, Hao, Bao, Yunyang, Niu, Shuaishuai, Wang, Shaorong, Li, Yiming, He, Hongwei, Zhang, Na, Fang, Weishuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221314/
https://www.ncbi.nlm.nih.gov/pubmed/37242541
http://dx.doi.org/10.3390/ph16050758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221314/
https://www.ncbi.nlm.nih.gov/pubmed/37242541
http://dx.doi.org/10.3390/ph16050758

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