Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several studies have demonstrated that the switch of the g...

Descripción completa

Detalles Bibliográficos
Autores principales: Dohrn, Stefanie, Kyeremateng, Samuel O., Bochmann, Esther, Sobich, Ekaterina, Wahl, Andrea, Liepold, Bernd, Sadowski, Gabriele, Degenhardt, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221441/
https://www.ncbi.nlm.nih.gov/pubmed/37242781
http://dx.doi.org/10.3390/pharmaceutics15051539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221441/
https://www.ncbi.nlm.nih.gov/pubmed/37242781
http://dx.doi.org/10.3390/pharmaceutics15051539

Ejemplares similares