Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several studies have demonstrated that the switch of the g...

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Detalles Bibliográficos
Autores principales: Dohrn, Stefanie, Kyeremateng, Samuel O., Bochmann, Esther, Sobich, Ekaterina, Wahl, Andrea, Liepold, Bernd, Sadowski, Gabriele, Degenhardt, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221441/
https://www.ncbi.nlm.nih.gov/pubmed/37242781
http://dx.doi.org/10.3390/pharmaceutics15051539

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