DHFR Inhibitors Display a Pleiotropic Anti-Viral Activity against SARS-CoV-2: Insights into the Mechanisms of Action

During the COVID-19 pandemic, drug repurposing represented an effective strategy to obtain quick answers to medical emergencies. Based on previous data on methotrexate (MTX), we evaluated the anti-viral activity of several DHFR inhibitors in two cell lines. We observed that this class of compounds s...

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Detalles Bibliográficos
Autores principales: Iaconis, Daniela, Caccuri, Francesca, Manelfi, Candida, Talarico, Carmine, Bugatti, Antonella, Filippini, Federica, Zani, Alberto, Novelli, Rubina, Kuzikov, Maria, Ellinger, Bernhard, Gribbon, Philip, Riecken, Kristoffer, Esposito, Francesca, Corona, Angela, Tramontano, Enzo, Beccari, Andrea Rosario, Caruso, Arnaldo, Allegretti, Marcello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221469/
https://www.ncbi.nlm.nih.gov/pubmed/37243214
http://dx.doi.org/10.3390/v15051128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221469/
https://www.ncbi.nlm.nih.gov/pubmed/37243214
http://dx.doi.org/10.3390/v15051128

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