Synthesis and Preliminary Characterization of Putative Anle138b-Centered PROTACs against α-Synuclein Aggregation

The search for disease-modifying agents targeted against Parkinson’s disease led us to rationally design a small array of six Anle138b-centered PROTACs, 7a,b, 8a,b and 9a,b, targeting αSynuclein (αSyn) aggregates for binding, polyubiquitination by the E3 ligase Cereblon (CRBN), and proteasomal degra...

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Detalles Bibliográficos
Autores principales: Pedrini, Martina, Iannielli, Angelo, Meneghelli, Lorenzo, Passarella, Daniele, Broccoli, Vania, Seneci, Pierfausto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221781/
https://www.ncbi.nlm.nih.gov/pubmed/37242709
http://dx.doi.org/10.3390/pharmaceutics15051467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10221781/
https://www.ncbi.nlm.nih.gov/pubmed/37242709
http://dx.doi.org/10.3390/pharmaceutics15051467

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