Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation

The bioequivalence of bempedoic acid oral suspension and commercial immediate release (IR) tablet formulations were assessed using a physiologically based pharmacokinetic (PBPK) model. The mechanistic model, developed from clinical mass balance results and in vitro intrinsic solubility, permeability...

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Detalles Bibliográficos
Autores principales: Amore, Benny M., Patel, Nikunjkumar, Batheja, Priya, Templeton, Ian E., Jones, Hannah M., Louie, Michael J., Emery, Maurice G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222242/
https://www.ncbi.nlm.nih.gov/pubmed/37242718
http://dx.doi.org/10.3390/pharmaceutics15051476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222242/
https://www.ncbi.nlm.nih.gov/pubmed/37242718
http://dx.doi.org/10.3390/pharmaceutics15051476

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