Glucolipotoxic Stress-Induced Mig6 Desensitizes EGFR Signaling and Promotes Pancreatic Beta Cell Death

A loss of functional beta cell mass is a final etiological event in the development of frank type 2 diabetes (T2D). To preserve or expand beta cells and therefore treat/prevent T2D, growth factors have been considered therapeutically but have largely failed to achieve robust clinical success. The mo...

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Detalles Bibliográficos
Autores principales: Chen, Yi-Chun, Lutkewitte, Andrew J., Basavarajappa, Halesha D., Fueger, Patrick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222246/
https://www.ncbi.nlm.nih.gov/pubmed/37233668
http://dx.doi.org/10.3390/metabo13050627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222246/
https://www.ncbi.nlm.nih.gov/pubmed/37233668
http://dx.doi.org/10.3390/metabo13050627

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