Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC(50) values of 3.6 nM and 33.9 nM, respectively. In order to identify the effects of loop2 size on the potency of TxID, alanine (Ala) insert...

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Detalles Bibliográficos
Autores principales: Dong, Jianying, Zhang, Panpan, Xie, Junjie, Xie, Ting, Zhu, Xiaopeng, Zhangsun, Dongting, Yu, Jinpeng, Luo, Sulan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222858/
https://www.ncbi.nlm.nih.gov/pubmed/37233480
http://dx.doi.org/10.3390/md21050286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222858/
https://www.ncbi.nlm.nih.gov/pubmed/37233480
http://dx.doi.org/10.3390/md21050286

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