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Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC(50) values of 3.6 nM and 33.9 nM, respectively. In order to identify the effects of loop2 size on the potency of TxID, alanine (Ala) insert...
Autores principales: | Dong, Jianying, Zhang, Panpan, Xie, Junjie, Xie, Ting, Zhu, Xiaopeng, Zhangsun, Dongting, Yu, Jinpeng, Luo, Sulan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10222858/ https://www.ncbi.nlm.nih.gov/pubmed/37233480 http://dx.doi.org/10.3390/md21050286 |
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