Application of Modelling and Simulation Approaches to Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies in Pediatric Population

Ethical regulations and limited paediatric participants are key challenges that contribute to a median delay of 6 years in paediatric mAb approval. To overcome these barriers, modelling and simulation methodologies have been adopted to design optimized paediatric clinical studies and reduce patient...

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Detalles Bibliográficos
Autores principales: Lim, Andrew, Sharma, Pradeep, Stepanov, Oleg, Reddy, Venkatesh Pilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223156/
https://www.ncbi.nlm.nih.gov/pubmed/37242793
http://dx.doi.org/10.3390/pharmaceutics15051552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223156/
https://www.ncbi.nlm.nih.gov/pubmed/37242793
http://dx.doi.org/10.3390/pharmaceutics15051552

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