A Novel Recognition by the E3 Ubiquitin Ligase of HSV-1 ICP0 Enhances the Degradation of PML Isoform I to Prevent ND10 Reformation in Late Infection

Upon viral entry, components of ND10 nuclear bodies converge with incoming DNA to repress viral expression. The infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) contains a RING-type E3 ubiquitin ligase that targets the ND10 organizer, PML, for proteasomal degradation. Consequently, N...

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Detalles Bibliográficos
Autores principales: Jan Fada, Behdokht, Guha, Udayan, Zheng, Yi, Reward, Eleazar, Kaadi, Elie, Dourra, Ayette, Gu, Haidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223204/
https://www.ncbi.nlm.nih.gov/pubmed/37243155
http://dx.doi.org/10.3390/v15051070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223204/
https://www.ncbi.nlm.nih.gov/pubmed/37243155
http://dx.doi.org/10.3390/v15051070

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