Exploring the Role of Anionic Lipid Nanodomains in the Membrane Disruption and Protein Folding of Human Islet Amyloid Polypeptide Oligomers on Lipid Membrane Surfaces Using Multiscale Molecular Dynamics Simulations

The aggregation of human Islet Amyloid Polypeptide (hIAPP) on cell membranes is linked to amyloid diseases. However, the physio-chemical mechanisms of how these hIAPP aggregates trigger membrane damage are unclear. Using coarse-grained and all-atom molecular dynamics simulations, we investigated the...

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Detalles Bibliográficos
Autores principales: Nguyen, Ngoc, Lewis, Amber, Pham, Thuong, Sikazwe, Donald, Cheng, Kwan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223233/
https://www.ncbi.nlm.nih.gov/pubmed/37241931
http://dx.doi.org/10.3390/molecules28104191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223233/
https://www.ncbi.nlm.nih.gov/pubmed/37241931
http://dx.doi.org/10.3390/molecules28104191

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