Platelet Rich Plasma and Adipose-Derived Mesenchymal Stem Cells Mitigate Methotrexate-Induced Nephrotoxicity in Rat via Nrf2/Pparγ/HO-1 and NF-Κb/Keap1/Caspase-3 Signaling Pathways: Oxidative Stress and Apoptosis Interplay

Background: the nephrotoxicity of methotrexate (MTX) is observed in high-dose therapy. Moreover, low-dose MTX therapy for rheumatic diseases is debatable and claimed to cause renal impairment. This study aimed at studying the effect of methotrexate in repeated low doses on rat kidneys and assessing...

Descripción completa

Detalles Bibliográficos
Autores principales: Wani, Farooq A., Ibrahim, Mahrous A., Ameen, Shimaa H., Farage, Amira E., Ali, Zinab Abd-Elhady, Saleh, Khaldoon, Farag, Medhat M., Sayeed, Mohammed U., Alruwaili, Muhannad A. Y., Alruwaili, Abdulsalam H. F., Aljared, Ahmad Z. A., Galhom, Rania A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223329/
https://www.ncbi.nlm.nih.gov/pubmed/37235213
http://dx.doi.org/10.3390/toxics11050398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223329/
https://www.ncbi.nlm.nih.gov/pubmed/37235213
http://dx.doi.org/10.3390/toxics11050398

Ejemplares similares