Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

The clinical usefulness of doxorubicin (DOX) is limited by its serious adverse effects, such as cardiotoxicity. Pregnenolone demonstrated both anti-inflammatory and antioxidant activity in animal models. The current study aimed to investigate the cardioprotective potential of pregnenolone against DO...

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Detalles Bibliográficos
Autores principales: Morsy, Mohamed A., Abdel-Gaber, Seham A., Mokhemer, Sahar A., Kandeel, Mahmoud, Sedik, Wael F., Nair, Anroop B., Venugopala, Katharigatta N., Khalil, Hany Ezzat, Al-Dhubiab, Bandar E., Mohamed, Mervat Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223417/
https://www.ncbi.nlm.nih.gov/pubmed/37242448
http://dx.doi.org/10.3390/ph16050665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223417/
https://www.ncbi.nlm.nih.gov/pubmed/37242448
http://dx.doi.org/10.3390/ph16050665

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