Preparation and In Vitro and In Vivo Evaluation of Rectal In Situ Gel of Meloxicam Hydroxypropyl-β-cyclodextrin Inclusion Complex

Meloxicam (MLX) is one of the most effective NSAIDs, but its poor water solubility and low bioavailability limit its clinical application. In this study, we designed a thermosensitive in situ gel of the hydroxypropyl-β-cyclodextrin inclusion complex (MLX/HP-β-CD-ISG) for rectal delivery to improve b...

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Detalles Bibliográficos
Autores principales: Lei, Xiaomeng, Zhang, Guansheng, Yang, Tao, Wu, Yuhuan, Peng, Ying, Wang, Tiantian, Li, Dongxun, Liu, Qian, Wang, Canjian, Zhang, Guosong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223448/
https://www.ncbi.nlm.nih.gov/pubmed/37241839
http://dx.doi.org/10.3390/molecules28104099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223448/
https://www.ncbi.nlm.nih.gov/pubmed/37241839
http://dx.doi.org/10.3390/molecules28104099

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