Viral Fitness of Baloxavir-Resistant Recombinant Influenza B/Victoria- and B/Yamagata-like Viruses Harboring the I38T PA Change, In Vitro, Ex Vivo and in Guinea Pigs

Seasonal influenza A and B viruses may cause severe infections requiring therapeutic interventions. Baloxavir, the latest antiviral drug approved against those infections, targets the endonuclease activity encoded by the polymerase acidic (PA) protein. While appearing effective at cessation of viral...

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Detalles Bibliográficos
Autores principales: Saim-Mamoun, Amel, Carbonneau, Julie, Rhéaume, Chantal, Abed, Yacine, Boivin, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223713/
https://www.ncbi.nlm.nih.gov/pubmed/37317069
http://dx.doi.org/10.3390/microorganisms11051095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223713/
https://www.ncbi.nlm.nih.gov/pubmed/37317069
http://dx.doi.org/10.3390/microorganisms11051095

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