Discovery of AI-2 Quorum Sensing Inhibitors Targeting the LsrK/HPr Protein–Protein Interaction Site by Molecular Dynamics Simulation, Virtual Screening, and Bioassay Evaluation

Quorum sensing (QS) is a cell-to-cell communication mechanism that regulates bacterial pathogenicity, biofilm formation, and antibiotic sensitivity. Among the identified quorum sensing, AI-2 QS exists in both Gram-negative and Gram-positive bacteria and is responsible for interspecies communication....

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Detalles Bibliográficos
Autores principales: Xu, Yijie, Zeng, Chunlan, Wen, Huiqi, Shi, Qianqian, Zhao, Xu, Meng, Qingbin, Li, Xingzhou, Xiao, Junhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223898/
https://www.ncbi.nlm.nih.gov/pubmed/37242520
http://dx.doi.org/10.3390/ph16050737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223898/
https://www.ncbi.nlm.nih.gov/pubmed/37242520
http://dx.doi.org/10.3390/ph16050737

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