ATF2 loss promotes 5-FU resistance in colon cancer cells via activation of the ATR-Chk1 damage response pathway

BACKGROUND: The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resistance. 5-Fluorouracil (5-FU) is the best-known chemotherapeutic drug for CC, but...

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Detalles Bibliográficos
Autores principales: Yang, Hao, Huebner, Kerstin, Hampel, Chuanpit, Erlenbach-Wuensch, Katharina, Selvamani, Selva Babu, Shukla, Vikas, Geppert, Carol I., Hartmann, Arndt, Mahadevan, Vijayalakshmi, Schneider-Stock, Regine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223906/
https://www.ncbi.nlm.nih.gov/pubmed/37237279
http://dx.doi.org/10.1186/s12885-023-10940-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10223906/
https://www.ncbi.nlm.nih.gov/pubmed/37237279
http://dx.doi.org/10.1186/s12885-023-10940-0

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