Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in “Super-Open” Conformation

The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic pocket of the “super-open” conformation of ZIKV NS2B...

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Detalles Bibliográficos
Autores principales: Meewan, Ittipat, Shiryaev, Sergey A., Kattoula, Julius, Huang, Chun-Teng, Lin, Vivian, Chuang, Chiao-Han, Terskikh, Alexey V., Abagyan, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224173/
https://www.ncbi.nlm.nih.gov/pubmed/37243192
http://dx.doi.org/10.3390/v15051106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224173/
https://www.ncbi.nlm.nih.gov/pubmed/37243192
http://dx.doi.org/10.3390/v15051106

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