From Batch to the Semi-Continuous Flow Hydrogenation of pNB, pNZ-Protected Meropenem

Meropenem is currently the most common carbapenem in clinical applications. Industrially, the final synthetic step is characterized by a heterogeneous catalytic hydrogenation in batch mode with hydrogen and Pd/C. The required high-quality standard is very difficult to meet and specific conditions ar...

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Detalles Bibliográficos
Autores principales: Comito, Marziale, Monguzzi, Riccardo, Tagliapietra, Silvia, Maspero, Angelo, Palmisano, Giovanni, Cravotto, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224265/
https://www.ncbi.nlm.nih.gov/pubmed/37242564
http://dx.doi.org/10.3390/pharmaceutics15051322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224265/
https://www.ncbi.nlm.nih.gov/pubmed/37242564
http://dx.doi.org/10.3390/pharmaceutics15051322

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