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From Batch to the Semi-Continuous Flow Hydrogenation of pNB, pNZ-Protected Meropenem
Meropenem is currently the most common carbapenem in clinical applications. Industrially, the final synthetic step is characterized by a heterogeneous catalytic hydrogenation in batch mode with hydrogen and Pd/C. The required high-quality standard is very difficult to meet and specific conditions ar...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224265/ https://www.ncbi.nlm.nih.gov/pubmed/37242564 http://dx.doi.org/10.3390/pharmaceutics15051322 |