Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer

Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it...

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Autores principales: Schubert, Melanie, Bauerschlag, Dirk Olaf, Muallem, Mustafa Zelal, Maass, Nicolai, Alkatout, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224285/
https://www.ncbi.nlm.nih.gov/pubmed/37241157
http://dx.doi.org/10.3390/medicina59050925
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author Schubert, Melanie
Bauerschlag, Dirk Olaf
Muallem, Mustafa Zelal
Maass, Nicolai
Alkatout, Ibrahim
author_facet Schubert, Melanie
Bauerschlag, Dirk Olaf
Muallem, Mustafa Zelal
Maass, Nicolai
Alkatout, Ibrahim
author_sort Schubert, Melanie
collection PubMed
description Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it possible to provide individualized surgical and drug treatment. In industrialized countries, cervical cancer has become a less frequent tumor entity due to the accessibility of the human papilloma virus vaccination, systematic preventive programs/early detection programs, health care infrastructure and the availability of effective therapy options. Nevertheless, globally, neither mortality nor morbidity has been significantly reduced over the past 10 years, and therapy approaches differ widely. The aim of this review is to address recent advances in the prevention, diagnostic investigation and treatment of cervical cancer globally, focusing on advances in Germany, with a view toward providing an updated overview for clinicians. The following aspects are addressed in detail: (a) the prevalence and causes of cervical cancer, (b) diagnostic tools using imaging techniques, cytology and pathology, (c) pathomechanisms and clinical symptoms of cervical cancer and (d) different treatment approaches (pharmacological, surgical and others) and their impact on outcomes.
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spelling pubmed-102242852023-05-28 Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer Schubert, Melanie Bauerschlag, Dirk Olaf Muallem, Mustafa Zelal Maass, Nicolai Alkatout, Ibrahim Medicina (Kaunas) Review Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it possible to provide individualized surgical and drug treatment. In industrialized countries, cervical cancer has become a less frequent tumor entity due to the accessibility of the human papilloma virus vaccination, systematic preventive programs/early detection programs, health care infrastructure and the availability of effective therapy options. Nevertheless, globally, neither mortality nor morbidity has been significantly reduced over the past 10 years, and therapy approaches differ widely. The aim of this review is to address recent advances in the prevention, diagnostic investigation and treatment of cervical cancer globally, focusing on advances in Germany, with a view toward providing an updated overview for clinicians. The following aspects are addressed in detail: (a) the prevalence and causes of cervical cancer, (b) diagnostic tools using imaging techniques, cytology and pathology, (c) pathomechanisms and clinical symptoms of cervical cancer and (d) different treatment approaches (pharmacological, surgical and others) and their impact on outcomes. MDPI 2023-05-11 /pmc/articles/PMC10224285/ /pubmed/37241157 http://dx.doi.org/10.3390/medicina59050925 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schubert, Melanie
Bauerschlag, Dirk Olaf
Muallem, Mustafa Zelal
Maass, Nicolai
Alkatout, Ibrahim
Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title_full Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title_fullStr Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title_full_unstemmed Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title_short Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
title_sort challenges in the diagnosis and individualized treatment of cervical cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224285/
https://www.ncbi.nlm.nih.gov/pubmed/37241157
http://dx.doi.org/10.3390/medicina59050925
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