Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles

The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an affinity for binding to desmolase, an enzyme i...

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Detalles Bibliográficos
Autores principales: Edris, Alaa, Abdelrahman, Mohammed, Osman, Wadah, Sherif, Asmaa E., Ashour, Ahmed, Garelnabi, Elrashied A. E., Ibrahim, Sabrin R. M., Bafail, Rawan, Samman, Waad A., Ghazawi, Kholoud F., Mohamed, Gamal A., Alzain, Abdulrahim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224385/
https://www.ncbi.nlm.nih.gov/pubmed/37233624
http://dx.doi.org/10.3390/metabo13050583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224385/
https://www.ncbi.nlm.nih.gov/pubmed/37233624
http://dx.doi.org/10.3390/metabo13050583

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