Binding and Dynamics Demonstrate the Destabilization of Ligand Binding for the S688Y Mutation in the NMDA Receptor GluN1 Subunit

Encephalopathies are brain dysfunctions that lead to cognitive, sensory, and motor development impairments. Recently, the identification of several mutations within the N-methyl-D-aspartate receptor (NMDAR) have been identified as significant in the etiology of this group of conditions. However, a c...

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Detalles Bibliográficos
Autores principales: Chen, Jake Zheng, Church, William Bret, Bastard, Karine, Duff, Anthony P., Balle, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224558/
https://www.ncbi.nlm.nih.gov/pubmed/37241849
http://dx.doi.org/10.3390/molecules28104108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224558/
https://www.ncbi.nlm.nih.gov/pubmed/37241849
http://dx.doi.org/10.3390/molecules28104108

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