Apigenin Attenuates Hippocampal Microglial Activation and Restores Cognitive Function in Methotrexate-Treated Rats: Targeting the miR-15a/ROCK-1/ERK1/2 Pathway

Microglial activation underpins the methotrexate (MTX)-induced neurotoxicity; however, the precise mechanism remains unclear. This study appraised the potential impact of apigenin (Api), a neuroprotective flavonoid, in MTX-induced neurotoxicity in rats in terms of microglial activation through targe...

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Detalles Bibliográficos
Autores principales: Taha, Mohamed, Eldemerdash, Omar Mohsen, Elshaffei, Ismail Mohamed, Yousef, Einas Mohamed, Soliman, Ayman S., Senousy, Mahmoud Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224822/
https://www.ncbi.nlm.nih.gov/pubmed/36943623
http://dx.doi.org/10.1007/s12035-023-03299-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224822/
https://www.ncbi.nlm.nih.gov/pubmed/36943623
http://dx.doi.org/10.1007/s12035-023-03299-7

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