The Aldose Reductase Inhibitor Epalrestat Maintains Blood–Brain Barrier Integrity by Enhancing Endothelial Cell Function during Cerebral Ischemia

Excessive activation of aldose reductase (AR) in the brain is a risk factor for aggravating cerebral ischemia injury. Epalrestat is the only AR inhibitor with proven safety and efficacy, which is used in the clinical treatment of diabetic neuropathy. However, the molecular mechanisms underlying the...

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Detalles Bibliográficos
Autores principales: Zhang, Tongshuai, Wu, Jinrong, Yao, Xinmin, Zhang, Yao, Wang, Yue, Han, Yang, Wu, Yun, Xu, Zhenyu, Lan, Jing, Han, Siyu, Zou, Haifeng, Sun, Qixu, Wang, Dandan, Zhang, Jingyu, Wang, Guangyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224835/
https://www.ncbi.nlm.nih.gov/pubmed/36940077
http://dx.doi.org/10.1007/s12035-023-03304-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224835/
https://www.ncbi.nlm.nih.gov/pubmed/36940077
http://dx.doi.org/10.1007/s12035-023-03304-z

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