Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue

At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized respiration. This is consistent with ΔΨ-dependent OAA inhibition of succinate dehydrogenase. To assess the metabolic importance of this process, we tes...

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Detalles Bibliográficos
Autores principales: Yu, Liping, Fink, Brian D., Som, Ritu, Rauckhorst, Adam J., Taylor, Eric B., Sivitz, William I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225247/
https://www.ncbi.nlm.nih.gov/pubmed/36272463
http://dx.doi.org/10.1016/j.bbabio.2022.148930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225247/
https://www.ncbi.nlm.nih.gov/pubmed/36272463
http://dx.doi.org/10.1016/j.bbabio.2022.148930

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