Comparing synaptic proteomes across five mouse models for autism reveals converging molecular similarities including deficits in oxidative phosphorylation and Rho GTPase signaling

Specific and effective treatments for autism spectrum disorder (ASD) are lacking due to a poor understanding of disease mechanisms. Here we test the idea that similarities between diverse ASD mouse models are caused by deficits in common molecular pathways at neuronal synapses. To do this, we levera...

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Detalles Bibliográficos
Autores principales: Carbonell, Abigail U., Freire-Cobo, Carmen, Deyneko, Ilana V., Dobariya, Saunil, Erdjument-Bromage, Hediye, Clipperton-Allen, Amy E., Page, Damon T., Neubert, Thomas A., Jordan, Bryen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225639/
https://www.ncbi.nlm.nih.gov/pubmed/37255534
http://dx.doi.org/10.3389/fnagi.2023.1152562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225639/
https://www.ncbi.nlm.nih.gov/pubmed/37255534
http://dx.doi.org/10.3389/fnagi.2023.1152562

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