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Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

Tumor suppressor p53 can transcriptionally activate downstream genes in response to stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis, and other biological responses. p53 has seven functional domains and 12 splice isoforms, and different domains and subtypes p...

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Detalles Bibliográficos
Autores principales: Shen, Jinze, Wang, Qurui, Mao, Yunan, Gao, Wei, Duan, Shiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225743/
https://www.ncbi.nlm.nih.gov/pubmed/37256211
http://dx.doi.org/10.1002/mco2.288