Prodrug Strategies for the Development of β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU) against Varicella Zoster Virus (VZV)

[Image: see text] Varicella zoster virus (VZV) establishes lifelong infection after primary disease and can reactivate. Several drugs are approved to treat VZV diseases, but new antivirals with greater potency are needed. Previously, we identified β-l-5-((E)-2-bromovinyl)-1-((2S,4S)-2-(hydroxymethyl...

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Detalles Bibliográficos
Autores principales: Singh, Uma S., Konreddy, Ananda K., Kothapalli, Yugandhar, Liu, Dongmei, Lloyd, Megan G., Annavarapu, Vidya, White, Catherine A., Bartlett, Michael. G., Moffat, Jennifer F., Chu, Chung K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226046/
https://www.ncbi.nlm.nih.gov/pubmed/37140467
http://dx.doi.org/10.1021/acs.jmedchem.3c00545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226046/
https://www.ncbi.nlm.nih.gov/pubmed/37140467
http://dx.doi.org/10.1021/acs.jmedchem.3c00545

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