Cargando…

Non-steroidal CYP17A1 Inhibitors: Discovery and Assessment

[Image: see text] CYP17A1 is an enzyme that plays a major role in steroidogenesis and is critically involved in the biosynthesis of steroid hormones. Therefore, it remains an attractive target in several serious hormone-dependent cancer diseases, such as prostate cancer and breast cancer. The medici...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wróbel, Tomasz M., Jørgensen, Flemming Steen, Pandey, Amit V., Grudzińska, Angelika, Sharma, Katyayani, Yakubu, Jibira, Björkling, Fredrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226049/ https://www.ncbi.nlm.nih.gov/pubmed/37191389 http://dx.doi.org/10.1021/acs.jmedchem.3c00442

Ejemplares similares

Synthesis and Structure–Activity Relationships of Novel Non-Steroidal CYP17A1 Inhibitors as Potential Prostate Cancer Agents
por: Wróbel, Tomasz M., et al.
Publicado: (2022)

Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents
por: Wróbel, Tomasz M., et al.
Publicado: (2020)

Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
por: Wróbel, Tomasz M., et al.
Publicado: (2023)

Promising Tools in Prostate Cancer Research: Selective Non-Steroidal Cytochrome P450 17A1 Inhibitors
por: Bonomo, Silvia, et al.
Publicado: (2016)

Synthesis, Structural and Behavioral Studies of Indole Derivatives D2AAK5, D2AAK6 and D2AAK7 as Serotonin 5-HT(1A) and 5-HT(2A) Receptor Ligands
por: Kaczor, Agnieszka A., et al.
Publicado: (2023)

Structure-based discovery of selective CYP(17)A(1) inhibitors for Castration-resistant prostate cancer treatment
por: Omoboyowa, Damilola A, et al.
Publicado: (2021)

No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.
por: Dunning, A. M., et al.
Publicado: (1998)

Low-Dose Sodium Salicylate Promotes Ovulation by Regulating Steroids via CYP17A1
por: Li, Tao, et al.
Publicado: (2023)

A novel CYP17A1 deletion causes a functional knockout of the steroid enzyme 17-hydroxylase and 17,20-lyase in a Turkish family and illustrates the precise role of the CYP17A1 gene
por: Camats, Núria, et al.
Publicado: (2015)

Influence of CYP2C19*2/*17 genotype on adverse drug reactions of voriconazole in patients after allo-HSCT: a four-case report
por: Beata, Sienkiewicz, et al.
Publicado: (2017)

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies
por: Khalil, Nadia A., et al.
Publicado: (2021)

Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei
por: Kelly, John M., et al.
Publicado: (2012)

The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro
por: Jibira, Yakubu, et al.
Publicado: (2020)

Exploring the Chemical Space of CYP17A1 Inhibitors Using Cheminformatics and Machine Learning
por: Yu, Tianshi, et al.
Publicado: (2023)

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn
por: Adusei, Emmanuel B. A., et al.
Publicado: (2019)

Lantana camara leaf extract ameliorates memory deficit and the neuroinflammation associated with scopolamine-induced Alzheimer’s-like cognitive impairment in zebrafish and mice
por: Amoah, Veronica, et al.
Publicado: (2023)

Construction of antifungal dual-target (SE, CYP51) pharmacophore models and the discovery of novel antifungal inhibitors
por: Dong, Yue, et al.
Publicado: (2019)

Metabolomics-based discovery of XHP as a CYP3A4 inhibitor against pancreatic cancer
por: Yang, Yuting, et al.
Publicado: (2023)

Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity
por: Frederiksen, Nicki, et al.
Publicado: (2019)

Identification and Analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in Cynomolgus Macaques
por: UNO, Yasuhiro, et al.
Publicado: (2014)

Ibrutinib does not have clinically relevant interactions with oral contraceptives or substrates of CYP3A and CYP2B6
por: de Jong, Jan, et al.
Publicado: (2020)

Hydroethanolic Stem Bark Extract of Burkea africana Attenuates Vincristine-Induced Peripheral Neuropathy in Rats
por: Jibira, Yakubu, et al.
Publicado: (2020)

A family based study on T-C transition polymorphism in Cyp17a1 gene in Indian children
por: Gayan, Sukanya, et al.
Publicado: (2014)

A novel nonsense mutation in androgen receptor confers resistance to CYP17 inhibitor treatment in prostate cancer
por: Han, Dong, et al.
Publicado: (2016)

Amphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark
por: Asante-Kwatia, Evelyn, et al.
Publicado: (2021)

Mechanism of the Dual Activities of Human CYP17A1 and Binding to Anti-Prostate Cancer Drug Abiraterone Revealed by a Novel V366M Mutation Causing 17,20 Lyase Deficiency
por: Fernández-Cancio, Mónica, et al.
Publicado: (2018)

Evaluation of CYP17A1 and CYP1B1 polymorphisms in male breast cancer risk
por: Rizzolo, Piera, et al.
Publicado: (2019)

Antinociceptive effects of a hydroethanolic stem bark extract of Burkea africana
por: Jibira, Yakubu, et al.
Publicado: (2022)

Classification of CYP450 1A2 inhibitors using PubChem data
por: Novotarskyi, Sergii, et al.
Publicado: (2010)

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy
por: Hoobler, Eric K., et al.
Publicado: (2013)

Two cases of 17α-hydroxylase/17,20-lyase deficiency caused by the CYP17A1 mutation
por: Lee, Hae In, et al.
Publicado: (2021)

Steroid conversion with CYP106A2 – production of pharmaceutically interesting DHEA metabolites
por: Schmitz, Daniela, et al.
Publicado: (2014)

Comparisons of Prostate Cancer Inhibitors Abiraterone and TOK-001 Binding with CYP17A1 through Molecular Dynamics
por: Xiao, Fei, et al.
Publicado: (2015)

Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk
por: Bethke, Lara, et al.
Publicado: (2007)

Aldehyde Oxidase: Reaction Mechanism and Prediction of Site of Metabolism
por: Montefiori, Marco, et al.
Publicado: (2017)

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
por: Chernov-Rogan, Tania, et al.
Publicado: (2018)

Wound Management Property of a Hydroethanolic Leaf Extract of Cnestis ferruginea DC
por: Yakubu, Jibira, et al.
Publicado: (2021)

CYP17A1 Intron Mutation Causing Cryptic Splicing in 17α-Hydroxylase Deficiency
por: Hwang, Daw-Yang, et al.
Publicado: (2011)

A polymorphism in the CYP17 gene is associated with male breast cancer
por: Young, I E, et al.
Publicado: (1999)

CYP17 and breast cancer: no overall effect, but what about interactions?
por: Little, Julian, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_8156i188im3hkl192a617gt6cn