Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form

[Image: see text] Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible therapy for a range of human disorders. Herein, we present...

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Detalles Bibliográficos
Autores principales: Aarhus, Thomas Ihle, Bjørnstad, Frithjof, Wolowczyk, Camilla, Larsen, Kristin Uhlving, Rognstad, Line, Leithaug, Trygve, Unger, Anke, Habenberger, Peter, Wolf, Alexander, Bjørkøy, Geir, Pridans, Clare, Eickhoff, Jan, Klebl, Bert, Hoff, Bård H., Sundby, Eirik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226129/
https://www.ncbi.nlm.nih.gov/pubmed/37191268
http://dx.doi.org/10.1021/acs.jmedchem.3c00428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226129/
https://www.ncbi.nlm.nih.gov/pubmed/37191268
http://dx.doi.org/10.1021/acs.jmedchem.3c00428

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