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TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination
BACKGROUND: Excessive and unresolved neuroinflammation plays an important role in the pathophysiology of many neurological disorders, such as ischemic stroke, yet there are no effective treatments. Tripartite motif-containing 67 (TRIM67) plays a crucial role in the control of inflammatory disease an...
Autores principales: | Yu, Yongbo, Xia, Qian, Zhan, Gaofeng, Gao, Shuai, Han, Tangrui, Mao, Meng, Li, Xing, Wang, Yonghong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226213/ https://www.ncbi.nlm.nih.gov/pubmed/37248543 http://dx.doi.org/10.1186/s13578-023-01056-w |
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