GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model

BACKGROUND AND AIMS: The accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER) stress, which is a critical consequence in human disorders such as familial hypercholesterolemia, cardiovascular and hepatic diseases. In addition to the i...

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Detalles Bibliográficos
Autores principales: Varghese, Divya Saro, Oommen, Deepu, John, Anne, Ali, Bassam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226256/
https://www.ncbi.nlm.nih.gov/pubmed/37248472
http://dx.doi.org/10.1186/s12944-023-01835-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226256/
https://www.ncbi.nlm.nih.gov/pubmed/37248472
http://dx.doi.org/10.1186/s12944-023-01835-x

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